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Libby Day was only eight years old when her family was brutally murdered in their rural Kansas farmhouse. Almost thirty years later, she reluctantly agrees to revisit the crime and uncovers the wrenching truths that led up to that tragic night. Votes: 39, R min Comedy, Drama. Down on his luck and facing financial hardship, Gerry teams up with younger charismatic poker player, Curtis, in an attempt to change his luck.

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The two set off on a road trip through the South with visions of winning back what's been lost. R min Drama, Thriller. Held captive for 7 years in an enclosed space, a woman and her young son finally gain their freedom, allowing the boy to experience the outside world for the first time. R 93 min Drama, Thriller. R 92 min Drama, Horror, Mystery. A family in s New England is torn apart by the forces of witchcraft, black magic, and possession. R 94 min Drama, Mystery, Thriller. With the aid of a fellow Auschwitz survivor and a hand-written letter, an elderly man with dementia goes in search of the person he believes to be responsible for the death of his family in the death camp to kill him himself.

R 83 min Drama. Krisha returns for Thanksgiving dinner after ten years away from her family, but past demons threaten to ruin the festivities.

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R 95 min Horror, Music, Thriller. A punk rock band is forced to fight for survival after witnessing a murder at a neo-Nazi skinhead bar. R 87 min Crime, Drama, Thriller. Elliot, a troubled former successful writer decides to write about a missing wife and the following murder trial of her husband.

R min Comedy, Drama, Romance. In a dystopian near future, single people, according to the laws of The City, are taken to The Hotel, where they are obliged to find a romantic partner in forty-five days or are transformed into beasts and sent off into The Woods. R 97 min Comedy, Drama, Fantasy.

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A hopeless man stranded on a deserted island befriends a dead body and together they go on a surreal journey to get home. In an emotionless utopia, two people fall in love when they regain their feelings from a mysterious disease, causing tensions between them and their society. R min Drama, Sci-Fi, Thriller. After a massive power outage, two sisters learn to survive on their own in their isolated woodland home. R 91 min Comedy, Drama, Romance.

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The romantic and coming-of-age misadventures of a year-old American living in Germany. PG min Drama, Fantasy, Mystery. A suicidal American befriends a Japanese man lost in a forest near Mt. Fuji and the two search for a way out. R min Adventure, Drama, Romance.

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A teenage girl with nothing to lose joins a traveling magazine sales crew, and gets caught up in a whirlwind of hard partying, law bending and young love as she criss-crosses the Midwest with a band of misfits. R min Drama.

A young African-American man grapples with his identity and sexuality while experiencing the everyday struggles of childhood, adolescence, and burgeoning adulthood. An in-depth look at the life and music of Manchester-based rock band, Oasis. R 91 min Drama, Fantasy, Horror. A mother and daughter must confront a terrifying monster when they break down on a deserted road. Votes: 14, The story of a teenage boy, his mother, and two other women who help raise him among the love and freedom of Southern California of R 99 min Action, Crime, Drama. Votes: 6, Depression is a frequent internal cue triggering drug craving 7 , 8.

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As comorbid depression is associated with continued drug use, it has been hypothesized that depression is also associated with continued HIV risk-taking through sharing of drug equipment 9 , Higher scores on measures of psychological distress, inventories measuring symptoms of depression, and composite measures of depression, anxiety, and hostility have been associated with higher levels of injection-related risk taking 11 ā€” Within the last 10 years, nearly half of the new cases of HIV infection in the United States have been among injection drug users Because measures for reducing the occurrence of AIDS associated with injection drug use include encouraging safer injecting practices, depression might have considerable influence as a modifiable factor.

Previous reports linking depressive symptoms with injection risk behaviors have lacked diagnostic assessments and have not considered the severity of the depressive symptoms 9 ā€” This study examines the association of depression severity and injection risk behaviors in a cohort of active drug injectors. Between March and December , we recruited subjects in Providence, R. We multiplied the numbers they provided to estimate the total number of injections during the 90 days before the baseline interview. How many of these times did you use needles or syringes that someone else had used and were not sterilized or cleaned with bleach before you used them?

The primary predictor of interest was depression severity, which was assessed by using the modified Hamilton depression scale. Control variables included the total number of injections during the past 90 days; treatment involvement any residential, outpatient, or methadone treatment or drug detoxification during the past 90 days; use of benzodiazepines and noninjection cocaine, both of which are predictors of high-risk injecting practices 19 ā€” 21 ; and alcohol problems as assessed with the Addiction Severity Index We report results from bivariate and multivariate ordered logistic regression models We used the cumulative odds ratio as a measure of effect size.

Continuous predictor variables were standardized to zero mean and unit variance before analysis We report z statistics and confidence interval estimates based on robust standard error estimators Huber-White sandwich estimators The subjects had been injecting drugs for an average of The mean score on the modified Hamilton depression scale was During the day reporting period, subjects reported injecting drugs on an average of The mean number of reported injection risk instances in the past 90 days was Of the subjects, To control for potential confounding, we estimated a model with all nine selected predictor variables Table 1.

The magnitude of the adjusted association between injection risk behavior and the modified Hamilton depression scale score was 1. After adjustment for other covariates, an increase of one standard deviation in the total number of injections increased the cumulative odds of injection risk behavior by a factor of 1.

Other covariates were not statistically significant predictors of injection risk. Identifying and attempting to modify the predictors of risky injection behavior is one approach to the prevention of transmission of blood-borne viruses. In this study of depressed drug injectors, we found that greater severity of depression was associated with increased sharing of needles and syringes, placing users at risk for HIV and hepatitis.

These findings clarify the independent effect of psychiatric severity relative to other sociodemographic factors and frequency of drug injection. While injection frequency was associated with greater injection risk, depression did not increase injection frequency in the subjects in our study. There are alternative mechanisms by which depression may increase risk taking.

Fourth, depression may index a lesser ability to cope with stressful life events, leading to higher levels of unmindful sharing of drug equipment. Fifth, depression may be serving as a marker of additional psychiatric diagnoses, such as anxiety disorders, that have been associated with drug injection risk From to , an average of 41 new drugs was marketed per year in the United States [ 1 ]. As of January 1, , more than 3, prescription drugs were on the US market.

In recent years, the release of new molecular entities totals 24 entities in ; 17 in ; 21 in ; 36 in ; 20 in ; 22 in ; 18 in ; 24 in ; 26 in ; 21 in ; and 30 in [ 2 - 6 ]. Moreover, newer classes of medications e. This has left a gap in our ability to predict or confirm the potential ability of medications to cause lifethreatening reactions.

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These include [but are not limited to] chemotherapeutic agents and other blood products [ 10 - 13 ], anti-human immunodeficiency virus agents [ 14 , 15 ], nonsteroidal antiinflammatory drugs [ 16 ], tyrosine kinase inhibitors [ 17 ], anesthetic drugs [ 18 - 20 ], coagulation factors [ 21 , 22 ], allopurinol [ 23 ], bisphosphonates [ 24 ], thienopyridines [ 25 ], monoclonal antibodies [ 26 ], glucocorticoids [ 27 ], vaccines and vaccine components [ 28 , 29 ], and desferrioxamine [ 30 ], to mention a few. Also, some reactions to medications will neither be predicted nor diagnosed by skin or in vitro hypersensitivity testing [ 33 , 34 ].

However, skin testing for immunoglobulin Eā€” mediated sensitivity, drug challenges, and desensitization procedures are common, practical methods of approaching the patient with a suspected drug allergy. General guidelines have been published for skin testing for drug hypersensitivity, including the best time for testing after clinical symptoms have occurred, test preparations, test vehicles and concentrations, testing of patients at higher risk, and the use of controls [ 35 ]. Despite the current void of standardized skin test reagents, practicing physicians have continued to report their experiences with skin testing and desensitization [ 36 ] to a wide range of drugs.

Here, we have compiled the experiences with these procedures reported from through in three leading allergy journals. Issues of the Journal of Allergy and Clinical Immunology, Allergy, and Annals of Allergy, Asthma and Immunology from January through December were reviewed for reports of skin testing, challenge, or desensitization to medications.

Articles, including meeting abstracts, were included in this survey if they contained sufficiently detailed information pertaining to the procedure described [e. During the 5-year period, reports of drugs met the simple criteria described above. There were 39 different antibiotic drugs listed in 31 separate reports.

Other commonly-reported drugs included antineoplastic medications 10 drugs, 15 reports , corticosteroids 10 drugs, 5 reports , neuromuscular blocking drugs 8 drugs, 6 reports , local anesthetic agents 6 drugs, 7 reports hypnotics 6 drugs, 5 reports , opioid analgesics 5 drugs, 6 reports and COX-2 inhibitors 5 drugs, 9 reports. It was not surprising that commonly used medications were examined for hypersensitivity; however, testing was also performed on newer classes of available medications because of their increasing importance in clinical practice. Drug concentrations for epicutaneous and for intradermal skin tests are listed times and for patch tests 27 times.

Drug challenges 41 reports were also performed along with or in lieu of skin tests. For individual drugs the drug concentrations used for skin testing varied considerably and the type of testing utilized depended on the general route of administration for the drug itself, for example COX-2 inhibitors were generally tested by oral challenge whereas opioid analgesics were tested by epicutaneous and intradermal skin tests.

An alphabetical list of drugs, listed side effects, and concentrations used for epicutaneous, intradermal and patch skin tests as well as challenge and desensitization schedules are given in the Table1 [ 38 - ]. Adverse reactions to skin testing were reported 20 times in the current survey Table 1 included as supplementary data. These reactions were generally cutaneous itching, flushing, erythema, urticaria and delayed cutaneous reactions. Shortness of breath, wheezing, nausea, abdominal pain, and headache also were reported.

There were a total of 4 reports of anaphylaxis associated with intradermal testing with penicillin G, penicillin MDM, clavulanic acid, and with amoxicillin. In each of these instances epicutaneous testing had not been done. This suggests that skin testing is generally safe at the concentrations listed in the Table 1 included as supplementary data, but that the potential for anaphylaxis exists for penicillin-allergic patients who are solely tested intradermally without prior epicutaneous testing.